Maximum Doses

Drug	Plain	With adrenaline
Lignocaine	3 mg/kg	7 mg/kg
Bupivacaine	2 mg/kg	2 mg/kg
Ropivacaine	3 mg/kg	3 mg/kg
Prilocaine	6 mg/kg	8 mg/kg

Dose on lean body weight, since toxicity comes from the peak plasma level
Doses of different local anaesthetics add up
Use less in the elderly and in hepatic or cardiac impairment
Strength in mg/mL is the % × 10 (e.g. 1% = 10 mg/mL)

Local anaesthetic maximum dose

Maximum dose in mg and mL from the drug, strength and weight. Interactive on the website.

Toxicity

Initial IV bolus of 1.5 mL/kg of 20% lipid emulsion over 1 minute followed by an infusion at 15 mL/kg/h
- Give up to three bolus doses (two more) of lipid (1.5 mL/kg) at 5 minute intervals if:
  - Remains haemodynamically unstable
  - Adequate circulation deteriorates
- Continue the infusion until the patient is stable, double the rate to 30 mL/kg/h at any time after 5 minutes if:
  - Haemodnyamically unstable
  - Adequate circulation deteriorates
- Do not exceed a maximum dose of 12 mL/kg